Structure of PDB 8ffo Chain A

Receptor sequence

>8ffoA (length=604) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]

WEQYRDRVNMLQQERIRDSPLLQAAKENDLRLLKILLLNQDFQQRGAVGE
TALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNL
NLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR
LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDELQSLEL
VPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEID
SWGEELSFLELVVSSKKREARQILEQTPVKELVSFKWKKYGRPYFCVLAS
LYILYMICFTTCCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNI
RLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTILGGPFHVIIITYAS
LVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTIMIQK
MIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTF
ELFLTIIDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWR
VAQERDELWRAQVVATTVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVE
NHHD

3D structure

PDB

8ffo Structural basis of the activation of TRPV5 channels by long-chain acyl-Coenzyme-A.

Chain

Resolution

3.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ERG	A	F425 I428 F456 V459 C463 T479 Q483 F487	F391 I394 F422 V425 C429 T445 Q449 F453
BS02	CPL	A	Y377 E389 M440	Y343 E355 M406
BS03	CPL	A	E403 Y467	E369 Y433
BS04	ERG	A	M497 P527	M463 P493
BS05	PIO	A	R302 R305 F416 G417 P424 K484 F487 R584	R268 R271 F382 G383 P390 K450 F453 R550
BS06	CPL	A	I341 I348 Y349	I307 I314 Y315
BS07	CPL	A	A498 L502 Y526 L530	A464 L468 Y492 L496

Gene Ontology

	Molecular Function
GO:0005216	monoatomic ion channel activity
GO:0005261	monoatomic cation channel activity
GO:0005262	calcium channel activity
GO:0005516	calmodulin binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding

	Biological Process
GO:0006811	monoatomic ion transport
GO:0006816	calcium ion transport
GO:0035809	regulation of urine volume
GO:0051289	protein homotetramerization
GO:0055074	calcium ion homeostasis
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0098703	calcium ion import across plasma membrane

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016324	apical plasma membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8ffo, PDBe:8ffo, PDBj:8ffo
PDBsum	8ffo
PubMed	37735536
UniProt	Q9XSM3\|TRPV5_RABIT Transient receptor potential cation channel subfamily V member 5 (Gene Name=Trpv5)

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