Structure of PDB 8ff0 Chain A

Receptor sequence
>8ff0A (length=265) Species: 10090 (Mus musculus) [Search protein sequence]
MEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIRMIREGSMSEDEFIE
EAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQ
TQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTR
YVLDDEYTSSTGSKFPVKWASPEVLMYSKFSSKSDIWAFGVLMWEIYSLG
KMPYERFTNSETAEHIAQGLRLPRPHLASERVYTIMYSCWHEKADERPSF
KILLSNILDVMDEES
3D structure
PDB8ff0 Structure of BTK kinase domain with the second-generation inhibitors acalabrutinib and tirabrutinib.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7GB A V416 A428 R430 M449 V458 T474 M477 C481 R525 L528 S538 D539 F540 M542 V22 A34 R36 M55 V64 T80 M83 C87 R131 L134 S144 D145 F146 M148
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8ff0, PDBe:8ff0, PDBj:8ff0
PDBsum8ff0
PubMed37651403
UniProtP35991|BTK_MOUSE Tyrosine-protein kinase BTK (Gene Name=Btk)

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