Structure of PDB 8fdu Chain A

Receptor sequence

>8fduA (length=1001) Species: 9606,300852

AKVPQIEVETHKVAAPDVVVPTLDTVRHEALLYTWLAEHKPLVLCGPPGS
GKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCEYRRTPNGVV
LAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGFYRTSDQT
WVKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYG
TFNRAMLRLIPSLRTYAEPLTAAMVEFYTMSQERFTQDTQPHYIYSPREM
TRWVRGIFEALRPLETLPVEGLIRIWAHEALRLFQDRLVEDEERRWTDEN
IDTVALKHFPNIDREKAMSRPILYSNWLSKDYIPVDQEELRDYVKARLKV
FYEEELDVPLVLFNEVLDHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRF
VAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNV
LDSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDSHEE
LYKWFTSQVIRNLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWST
EALYQVGKEFTSKMDLEKPNYIVPDYMPVVYDKLPQPPSHREAIVNSCVF
VHQTLHQANARLAKRGGRTMAITPRHYLDFINHYANLFHEKRSELEEQQM
HLNVGLRKIKETVDQVEELRRKVNRSTALLKSLSAERERWEKTSETFKNQ
MSTIAGDCLLSAAFIAYAGYFDQQMRQNLFTTWSHHLQQANIQFRTDIAR
TEYLSNADERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDPSGQATEF
IMNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVESYDPVLNPVL
NREVRRTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFV
NFTVTRSSLQSQCLNEVLKAERPDVDEKRSDLLKLQGEFQLRLRQLEKSL
LQALNEVKGRILDDDTIITTLENLKREAAEVTRKVEETDIVMQEVETVSQ
Q

3D structure

• PDB: 8fdu Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport.
• Chain: A
• Resolution: 3.3 Å

Enzymatic activity

• Enzyme Commision number: 6.1.1.11: serine--tRNA ligase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	A	V1113 G1143 S1144 G1145 K1146 T1147 M1148 I1292 R1342 T1345	V19 G49 S50 G51 K52 T53 M54 I198 R248 T251
BS02	ADP	A	V1452 P1453 L1454 V1455 S1484 G1485 A1486 G1487 K1488 T1489 T1490 W1642 L1722	V358 P359 L360 V361 S390 G391 A392 G393 K394 T395 T396 W548 L628

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0005524 ATP binding
• GO:0008569 minus-end-directed microtubule motor activity
• GO:0016887 ATP hydrolysis activity
• GO:0045505 dynein intermediate chain binding
• GO:0051959 dynein light intermediate chain binding

Biological Process

• GO:0007018 microtubule-based movement

Cellular Component

• GO:0030286 dynein complex

External links

• PDB: RCSB:8fdu, PDBe:8fdu, PDBj:8fdu
• PDBsum: 8fdu
• PubMed: 37322240
• UniProt: Q14204|DYHC1_HUMAN Cytoplasmic dynein 1 heavy chain 1 (Gene Name=DYNC1H1);
  Q5SJX7