Structure of PDB 8fda Chain A

Receptor sequence
>8fdaA (length=467) Species: 9606 (Homo sapiens) [Search protein sequence]
PKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVG
HHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRL
AMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTN
VISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNK
TLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDSEL
LSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV
GFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAV
DKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFG
AGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLI
DSFKVKIKVRQAWREAQ
3D structure
PDB8fda Selective steroidogenic cytochrome P450 haem iron ligation by steroid-derived isonitriles.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.14.19: steroid 17alpha-monooxygenase.
1.14.14.32: 17alpha-hydroxyprogesterone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A R96 I112 A113 R125 A302 T306 L361 L370 H373 P434 F435 R440 C442 G444 A448 R69 I85 A86 R98 A266 T270 L325 L334 H337 P398 F399 R404 C406 G408 A412
BS02 XPK A Y201 N202 I205 I206 A302 T306 I371 V483 Y174 N175 I178 I179 A266 T270 I335 V447
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0004508 steroid 17-alpha-monooxygenase activity
GO:0005506 iron ion binding
GO:0008395 steroid hydroxylase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016829 lyase activity
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0006694 steroid biosynthetic process
GO:0006702 androgen biosynthetic process
GO:0006704 glucocorticoid biosynthetic process
GO:0007548 sex differentiation
GO:0008202 steroid metabolic process
GO:0042445 hormone metabolic process
GO:0042446 hormone biosynthetic process
GO:0042448 progesterone metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0030424 axon
GO:0043025 neuronal cell body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fda, PDBe:8fda, PDBj:8fda
PDBsum8fda
PubMed37660137
UniProtP05093|CP17A_HUMAN Steroid 17-alpha-hydroxylase/17,20 lyase (Gene Name=CYP17A1)

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