Structure of PDB 8fbq Chain A

Receptor sequence
>8fbqA (length=385) Species: 126793 (Plasmodium vivax Sal-1) [Search protein sequence]
PDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYV
CDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTW
HIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLA
PVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIG
FSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQF
NLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGND
KYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSV
FEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL
3D structure
PDB8fbq Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts.
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.97: glycylpeptide N-tetradecanoyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MYA A Y28 K29 F30 W31 Y95 V96 L163 C164 V165 R170 S171 R173 A175 T183 I186 W192 A194 Y196 T197 L202 Y393 Y3 K4 F5 W6 Y70 V71 L138 C139 V140 R145 S146 R148 A150 T158 I161 W167 A169 Y171 T172 L177 Y368
BS02 XOQ A F105 T197 Y211 S319 Y334 F80 T172 Y186 S294 Y309
Gene Ontology
Molecular Function
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity
GO:0016746 acyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006499 N-terminal protein myristoylation
GO:0018008 N-terminal peptidyl-glycine N-myristoylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fbq, PDBe:8fbq, PDBj:8fbq
PDBsum8fbq
PubMed37669940
UniProtA5K1A2

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