Structure of PDB 8fbh Chain A

Receptor sequence
>8fbhA (length=232) Species: 10090 (Mus musculus) [Search protein sequence]
GKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKAT
DENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTL
QRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLT
LDKDRIIDAGPKGNYARFMNHCCQPNCEAQKWSVNGDTRVGLFALSDIKA
GTELTFNYNLECLGNGKTVCKCGAPNCSGFLG
3D structure
PDB8fbh Crystal structure of NSD1
ChainA
Resolution2.32 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.357: [histone H3]-lysine(36) N-dimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1921 C1968 C1970 C1975 C173 C220 C222 C227
BS02 ZN A C1793 C1795 C1803 C1809 C45 C47 C55 C61
BS03 ZN A C1803 C1818 C1823 C1829 C55 C70 C75 C81
BS04 SAM A R1850 W1852 T1892 N1893 F1894 Y1895 R1915 F1916 N1918 H1919 Y1956 N1963 R102 W104 T144 N145 F146 Y147 R167 F168 N170 H171 Y208 N215
Gene Ontology
Molecular Function
GO:0042054 histone methyltransferase activity
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:8fbh, PDBe:8fbh, PDBj:8fbh
PDBsum8fbh
PubMed
UniProtO88491|NSD1_MOUSE Histone-lysine N-methyltransferase, H3 lysine-36 specific (Gene Name=Nsd1)

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