Structure of PDB 8fbg Chain A

Receptor sequence

>8fbgA (length=217) Species: 10090 (Mus musculus) [Search protein sequence]

KPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRM
LLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKG
EFVNECVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNY
ARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGN
GKTVCKCGAPNCSGFLG

3D structure

PDB

8fbg Crystal structure of NSD1

Chain

Resolution

2.29 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

2.1.1.357: [histone H3]-lysine(36) N-dimethyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ZN	A	C1921 C1968 C1970 C1975	C158 C205 C207 C212
BS02	ZN	A	C1793 C1795 C1803 C1809	C30 C32 C40 C46
BS03	ZN	A	C1803 C1818 C1823 C1829	C40 C55 C60 C66
BS04	CA	A	C1793 C1818 C1823	C30 C55 C60
BS05	SAM	A	R1850 W1852 T1892 N1893 F1894 Y1895 R1915 F1916 N1918 H1919 Y1956 N1963 C1968 L1979	R87 W89 T129 N130 F131 Y132 R152 F153 N155 H156 Y193 N200 C205 L216
BS06	CA	A	C1793 N1811 C1818 C1823	C30 N48 C55 C60

Gene Ontology

	Molecular Function
GO:0042054	histone methyltransferase activity

	Cellular Component
GO:0005634	nucleus

View graph for
Molecular Function

View graph for
Cellular Component

External links

PDB	RCSB:8fbg, PDBe:8fbg, PDBj:8fbg
PDBsum	8fbg
PubMed
UniProt	O88491\|NSD1_MOUSE Histone-lysine N-methyltransferase, H3 lysine-36 specific (Gene Name=Nsd1)

[Back to BioLiP]