Structure of PDB 8fb2 Chain A

Receptor sequence
>8fb2A (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]
TPEAPYASLTEIEHLVQSVSKSYRETCQLRLEDLLRQRSNIFSREEVTGY
QRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELSQNDQIVLLKAGAM
EVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLS
ALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTH
RQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
3D structure
PDB8fb2 Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XO5 A M365 A368 V376 F377 F388 S404 H479 M107 A110 V118 F119 F130 S146 H221
BS02 XNX A W317 L324 T325 I328 M358 Q484 A496 A497 F498 L501 Y502 L505 F506 W59 L66 T67 I70 M100 Q226 A238 A239 F240 L243 Y244 L247 F248
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fb2, PDBe:8fb2, PDBj:8fb2
PDBsum8fb2
PubMed36793423
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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