Structure of PDB 8fay Chain A

Receptor sequence

>8fayA (length=393) Species: 9606 (Homo sapiens) [Search protein sequence]

LFRDVAEVTAFRGSLLSWYDQEKRDLPWRRRAEDEMDLDRRAYAVWVSEV
MLQQTQVATVINYYTGWMQKWPTLQDLASASLEEVNQLWAGLGYYSRGRR
LQEGARKVVEELGGHMPRTAETLQQLLPGVGRYTAGAIASIAFGQATGVV
DGNVARVLCRVRAIGADPSSTLVSQQLWGLAQQLVDPARPGDFNQAAMEL
GATVCTPQRPLCSQCPVESLCRARQRVEQEQLLASGSLPWDQTLGVVNFP
RKASRKPPREESSATCVLEQPGALGAQILLVQRPNSGLLAGLWEFPSVTW
EPSEQLQRKALLQELQRWAGPLPATHLRHLGEVVHTFSHIKLTYQVYGLA
LEGTVPPGARWLTQEEFHTAAVSTAMKKVFRVYQGQQPGTCMG

3D structure

PDB

8fay Human MUTYH adenine glycosylase bound to DNA containing a transition state analog (1N) paired with d(8-oxo-G)

Chain

Resolution

1.91 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.2.2.31: adenine glycosylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	Q139 Q141 G176 G178 Y179 Y180 K365 G396 L398 H444 F446 S447 H448 S487 T488	Q54 Q56 G91 G93 Y94 Y95 K256 G287 L289 H335 F337 S338 H339 S373 T374
BS02	dna	A	L137 Q138 Q139 T140 Q141 V142 R185 P213 G214 G216 Y218 T219 D236 G237 N238 R241	L52 Q53 Q54 T55 Q56 V57 R100 P128 G129 G131 Y133 T134 D151 G152 N153 R156
BS03	SF4	A	R245 C290 C297 C300 C306 R309 V355	R160 C205 C212 C215 C221 R224 V246

External links

PDB	RCSB:8fay, PDBe:8fay, PDBj:8fay
PDBsum	8fay
PubMed
UniProt	Q9UIF7\|MUTYH_HUMAN Adenine DNA glycosylase (Gene Name=MUTYH)

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