Structure of PDB 8f8y Chain A

Receptor sequence
>8f8yA (length=425) Species: 9606 (Homo sapiens) [Search protein sequence]
NMATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYH
CPNCEKTHGKSTLKKKSQLFIKELRSRTFPSAEDVVARVPGSQLTLGYME
EHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKD
CKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWVE
NYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKTFY
LIRPASANISLYERWRSASNHSEMFFADQVDKCYKCIVKQGQTLFIPSGW
IYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETA
CWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAEHE
DELPEHFKPSQLIKDLAKEIRLSEN
3D structure
PDB8f8y A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2.
ChainA
Resolution3.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y14 V16 T17 F19 M20 E22 W29 E39 I45 Y145 E150 V178 D179 Y182 Y15 V17 T18 F20 M21 E23 W30 E40 I46 Y126 E131 V159 D160 Y163
BS02 ZN A C23 C26 C53 C24 C27 C54
BS03 ZN A C8 H31 C34 C9 H32 C35
External links
PDB RCSB:8f8y, PDBe:8f8y, PDBj:8f8y
PDBsum8f8y
PubMed36596360
UniProtO75151|PHF2_HUMAN Lysine-specific demethylase PHF2 (Gene Name=PHF2)

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