Structure of PDB 8f8l Chain A

Receptor sequence
>8f8lA (length=344) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
MAGAITDQLRRYLHGRRRAAAHMGSDYDGLIADLEDFVLGGGKRLRPLFA
YWGWHAVASREPDPDVLLLFSALELLHAWALVHDDLIDRSATRRGRPTAQ
LRYAALHRDRDWRGSPDQFGMSAAILLGDLAQVWADDIVSKVCQSALAPD
AQRRVHRVWADIRNEVLGGQYLDIVAEASAAESIESAMNVATLKTACYTV
SRPLQLGTAAAADRSDVAAIFEHFGADLGVAFQLRDDVLGVFGDPAVTGK
PSGDDLKSGKRTVLVAEAVELADRSDPLAAKLLRTSIGTRLTDAQVRELR
TVIEAVGARAAAESRIAALTQRALATLASAPINATAKAGLSELA
3D structure
PDB8f8l The structure of Rv2173 from M. tuberculosis in APO-, IPP-, and DMAP-bound forms.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.1: dimethylallyltranstransferase.
2.5.1.10: (2E,6E)-farnesyl diphosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DMA A D84 R93 Q170 D84 R93 Q170
BS02 CA A D84 D88 D84 D88
BS03 CA A D84 D88 D84 D88
Gene Ontology
Molecular Function
GO:0004161 dimethylallyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006629 lipid metabolic process
GO:0008299 isoprenoid biosynthetic process
GO:0033384 geranyl diphosphate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8f8l, PDBe:8f8l, PDBj:8f8l
PDBsum8f8l
PubMed
UniProtO53507|GFPPS_MYCTU (2E,6E)-farnesyl diphosphate synthase (Gene Name=idsA2)

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