Structure of PDB 8f85 Chain A

Receptor sequence
>8f85A (length=163) Species: 362242 (Mycobacterium ulcerans Agy99) [Search protein sequence]
SVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSL
PAAHRPLPGRRNVVVTRQTGLVAHGAQVVGSLEQALSPAEPDAATWVIGG
AQIYALALPLANRCEVTEVDVDLPPEDEDALAPVLDQTWAGTSGEWLVSR
SGLRYRMHSYRRL
3D structure
PDB8f85 Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM851
ChainA
Resolution1.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.1.3: dihydrofolate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A W8 A9 I16 G21 I22 G45 R46 R47 T48 V67 T68 R69 I100 G102 A103 Q104 I105 W6 A7 I14 G19 I20 G43 R44 R45 T46 V65 T66 R67 I98 G100 A101 Q102 I103
BS02 XKI A I7 W8 I22 D29 L30 F33 L52 P53 H56 L59 R62 I100 I5 W6 I20 D27 L28 F31 L50 P51 H54 L57 R60 I98
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004146 dihydrofolate reductase activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0046452 dihydrofolate metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046655 folic acid metabolic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:8f85, PDBe:8f85, PDBj:8f85
PDBsum8f85
PubMed
UniProtA0PQG8

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