Structure of PDB 8f6p Chain A

Receptor sequence

>8f6pA (length=1091) Species: 6100,10116

HPVRRAAVKILVHSLFSMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAI
YTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIVMAYTTEFVDSALRTF
RVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQL
FMGNLRHKCVRNFTELNGTNGSVEADGLVWNSLDVYLNDPANYLLKNGTT
DVLLCGNSSDAGTCPEGYRCLKAGQNPDHGYTSFDSFAWAFLALFRLMTQ
DCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQ
ATIAETEEPFADLTITMCIVLNTLFMALEHYNMTAEFEEMLQVGNLVFTG
IFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGSVLRSFRLLRV
FKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNY
SELRHRISDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQS
LCLLVFLLVMVIGNLVVLNLFLALLLSSFWWRLRKTCYRIVEHSWFETFI
IFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY
GFKKYFTNAWCWLDFLIVDVSLVSLVANTIKSLRTLRALRPLRALSRFEG
MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEG
DLPLNYTIVNNKSECESFNVTGELYWTKVKVNFDNVGAGYLALLQVATFK
GWMDIMYAAVDSRGYEEQPQWEDNLYMYIYFVVFIIFGSFFTLNLFIGVI
IDNFNQQKKKLGGQDIFMTEEQKKYYNMMKKLGSKKPQQGFIFDIVTKQA
FDVTIMFLICLNMVTMMVETDDQSPEKVNILAKINLLFVAIFTGECIVKM
AALRHYYFTNSWNIFDFVVVILSIVGTVLSDITLFRVIRLARIGRILRLI
RGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAG
IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNG
SRGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVA

3D structure

• PDB: 8f6p Structural Basis for Inhibition of the Cardiac Sodium Channel by the Atypical Antiarrhythmic Drug Ranolazine
• Chain: A
• Resolution: 3.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	BMA	A	P1727 D1731 P1732	P1038 D1042 P1043
BS02	XHO	A	Q372 V406 C899 F1420 S1712 F1762 V1766	Q250 V284 C483 F749 S1023 F1073 V1077
BS03	6OU	A	S1303 T1306 Y1673 V1749 F1753 I1760	S632 T635 Y984 V1060 F1064 I1071
BS04	6OU	A	L1340 N1406 G1408 F1467 A1748 I1751	L669 N735 G737 F796 A1059 I1062
BS05	6OU	A	F363 C1541 M1544	F241 C860 M863
BS06	6OU	A	S1221 A1225 F1226 F1667 F1671 F1699	S558 A562 F563 F978 F982 F1010
BS07	6OU	A	G1504 S1592 W1593 F1596 R1646	G833 S911 W912 F915 R957
BS08	Y01	A	V729 I1345	V320 I674
BS09	Y01	A	L737 H739 N1406	L328 H330 N735
BS10	Y01	A	T1270 W1275	T607 W612
BS11	Y01	A	D332 K388 A1700	D210 K266 A1011
BS12	Y01	A	L1542 T1546 K1558 I1565	L861 T865 K877 I884
BS13	Y01	A	A360 W361 F363 L364 F367 Q915 L919	A238 W239 F241 L242 F245 Q499 L503
BS14	Y01	A	I389 F393	I267 F271
BS15	Y01	A	F222 I850 I853 F854 L917	F100 I434 I437 F438 L501
BS16	Y01	A	F1350 Y1447 M1448 Y1451 V1454	F679 Y776 M777 Y780 V783

Gene Ontology

Molecular Function

• GO:0003674 molecular_function
• GO:0005216 monoatomic ion channel activity
• GO:0005248 voltage-gated sodium channel activity
• GO:0005261 monoatomic cation channel activity

Biological Process

• GO:0006091 generation of precursor metabolites and energy
• GO:0006811 monoatomic ion transport
• GO:0006814 sodium ion transport
• GO:0008218 bioluminescence
• GO:0055085 transmembrane transport

Cellular Component

• GO:0001518 voltage-gated sodium channel complex
• GO:0005575 cellular_component
• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:8f6p, PDBe:8f6p, PDBj:8f6p
• PDBsum: 8f6p
• UniProt: P15389;
  P42212|GFP_AEQVI Green fluorescent protein (Gene Name=GFP)