Structure of PDB 8f4q Chain A

Receptor sequence

>8f4qA (length=319) Species: 10114 (Rattus) [Search protein sequence]

NQSAIDVVAEKPSVRLTPTMMLYSGDGSHLLKSGRYLQQELPVRIAHRIK
GFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQ
LLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHH
LALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGH
VAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDV
DLIIRISDRGGGIAHKDLDRVMDYHFTTAEFGFGLPTSRAYAEYLGGSLQ
LQSLQGIGTDVYLRLRHID

3D structure

PDB

8f4q Discovery of branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors acting as stabilizers or destabilizers

Chain

Resolution

2.151 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.4: [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ADP	A	N249 R252 A253 I290 V298 T304 T305 G337 L340	N222 R225 A226 I263 V271 T277 T278 G282 L285
BS02	XER	A	L68 I72 Y99 L128 L129 H132 R167 I170 R171	L41 I45 Y72 L101 L102 H105 R140 I143 R144
BS03	XER	A	R75 G78 S81 Y158 F159	R48 G51 S54 Y131 F132
BS04	XER	A	A208 L211 C212 K215 Y216 K248 R252	A181 L184 C185 K188 Y189 K221 R225

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0047323	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
GO:0106310	protein serine kinase activity

	Biological Process
GO:0006550	isoleucine catabolic process
GO:0006552	L-leucine catabolic process
GO:0006574	valine catabolic process
GO:0007283	spermatogenesis
GO:0008610	lipid biosynthetic process
GO:0009083	branched-chain amino acid catabolic process
GO:0010906	regulation of glucose metabolic process
GO:0016310	phosphorylation

	Cellular Component
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0045252	oxoglutarate dehydrogenase complex

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Molecular Function

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Cellular Component

External links

PDB	RCSB:8f4q, PDBe:8f4q, PDBj:8f4q
PDBsum	8f4q
PubMed
UniProt	Q00972\|BCKD_RAT Branched-chain alpha-ketoacid dehydrogenase kinase (Gene Name=Bckdk)

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