Structure of PDB 8f0s Chain A

Receptor sequence
>8f0sA (length=1113) Species: 6978,9606 [Search protein sequence]
IRRVAISTMVQPIFSYFIMITILIHCIFMIMPATQTTYILELVFLSIYTI
EVVVKVLARGFILHPFAYLRDPWNWLDFLVTLIGYITLVVYALRAFRVLR
SWRTVTIVPGWRTIVDALSLSITSLKDLVLLLLFSLSVFALIGLQLFMGN
LKHKCVKHFPADGSWGNFTDERWFNYTSNSSHWYIPDDWIEYPLCGNSSG
AGMCPPGYTCLQGYGGNPNYGYTSFDTFGWAFLSVFRLVTLDYWEDLYQL
ALRSAGPWHILFFIIVVFYGTFCFLNFILAVVVMSYTHMVKRADEEKVVL
SPFFELFIAVIIVLNITFMALDHHDMNIEFERILRTGNYIFTSIYIVEAV
LKIIALSPKFYFKDSWNVFDFIIVVFAILELGLVFRSFRLLRVFRLAKFW
PTLNNFMSVMTKSYGAFVNVMYVMFLLLFIFAIIGMQLFGMNYIDNMERF
PDGDLPRWNFTDFLHSFMIVFRALCGEWIESMWDCMLVGDWSCIPFFVAV
FFVGNLVILNLLIALLLNNYGWSNIRRVCFLLAKNKYFQKFVTAVLVITS
VLLALEDIYLPQRPVLVNITLYVDYVLTAFFVIEMIIMLFAVGFKKYFTS
KWYWLDFIVVVAYLLNFVLMCAGIEALQTLRLLRVFRLFRPLSKVNGMQV
VTSTLVEAVPHIFNVILVGIFFWLVFAIMGVQLFAGKFYKCVDENSTVLS
HEITMDRNDCLHENYTWENSPMNFDHVGNAYLSLLQVATFKGWLQIMNDA
IDSREVHKQPIRETNIYMYLYFIFFIVFGSFFILKLFVCILIDIFRQQRR
KAEGLSATDSRTQLIYRRAVMRTMSAKPVKRIPKNKIQGCIFDLVTNQAF
DISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLI
SLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYSPTLFRVIRLARIGR
ILRLVKGAKGIRLLLLALRKALRTLFNVSFLLFVIMFVYAVFGMEFFMHI
RDAGAIDDVYNFKTFGQSIILLFQLATSAGWDGVYFAIANEEDCRAPDHE
LGYPGNCGSRALGIAYLVSYLIITCLVVINMYAAVILDYVLEVYEDSKEG
LTDDDYDMFFEVW
3D structure
PDB8f0s Cryo-EM reveals an unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X80 A Y1203 W1204 N1206 I1243 G1247 M1248 I1267 R1268 R1271 R1274 Y881 W882 N884 I921 G925 M926 I943 R944 R947 R950
BS02 Y01 A S332 W391 F1307 S199 W258 F983
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005261 monoatomic cation channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006814 sodium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0001518 voltage-gated sodium channel complex
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8f0s, PDBe:8f0s, PDBj:8f0s
PDBsum8f0s
PubMed36975198
UniProtD0E0C2|SCNA1_PERAM Sodium channel protein PaFPC1;
Q15858|SCN9A_HUMAN Sodium channel protein type 9 subunit alpha (Gene Name=SCN9A)

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