Structure of PDB 8f0r Chain A

Receptor sequence
>8f0rA (length=1114) Species: 6978,9606 [Search protein sequence]
IRRVAISTMVQPIFSYFIMITILIHCIFMIMPATQTTYILELVFLSIYTI
EVVVKVLARGFILHPFAYLRDPWNWLDFLVTLIGYITLVVLYALRAFRVL
RSWRTVTIVPGWRTIVDALSLSITSLKDLVLLLLFSLSVFALIGLQLFMG
NLKHKCVKHFPADGSWGNFTDERWFNYTSNSSHWYIPDDWIEYPLCGNSS
GAGMCPPGYTCLQGYGGNPNYGYTSFDTFGWAFLSVFRLVTLDYWEDLYQ
LALRSAGPWHILFFIIVVFYGTFCFLNFILAVVVMSYTHMVKRADEEKVV
LSPFFELFIAVIIVLNITFMALDHHDMNIEFERILRTGNYIFTSIYIVEA
VLKIIALSPKFYFKDSWNVFDFIIVVFAILELGLVFRSFRLLRVFRLAKF
WPTLNNFMSVMTKSYGAFVNVMYVMFLLLFIFAIIGMQLFGMNYIDNMER
FPDGDLPRWNFTDFLHSFMIVFRALCGEWIESMWDCMLVGDWSCIPFFVA
VFFVGNLVILNLLIALLLNNYGWSNIRRVCFLLAKNKYFQKFVTAVLVIT
SVLLALEDIYLPQRPVLVNITLYVDYVLTAFFVIEMIIMLFAVGFKKYFT
SKWYWLDFIVVVAYLLNFVLMCAGIEALQTLRLLRVFRLFRPLSKVNGMQ
VVTSTLVEAVPHIFNVILVGIFFWLVFAIMGVQLFAGKFYKCVDENSTVL
SHEITMDRNDCLHENYTWENSPMNFDHVGNAYLSLLQVATFKGWLQIMND
AIDSREVHKQPIRETNIYMYLYFIFFIVFGSFFILKLFVCILIDIFRQQR
RKAEGLSATDSRTQLIYRRAVMRTMSAKPVKRIPKNKIQGCIFDLVTNQA
FDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKL
ISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYSPTLFRVIRLARIG
RILRLVKGAKGIRLLLLALRKALRTLFNVSFLLFVIMFVYAVFGMEFFMH
IRDAGAIDDVYNFKTFGQSIILLFQLATSAGWDGVYFAIANEEDCRAPDH
ELGYPGNCGSRALGIAYLVSYLIITCLVVINMYAAVILDYVLEVYEDSKE
GLTDDDYDMFFEVW
3D structure
PDB8f0r Cryo-EM reveals an unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X7W A N1206 V1207 G1247 M1248 D1252 R1268 A1270 R1274 N885 V886 G926 M927 D931 R945 A947 R951
BS02 Y01 A S332 P390 W391 L394 F1307 S200 P258 W259 L262 F984
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005261 monoatomic cation channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006814 sodium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0001518 voltage-gated sodium channel complex
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8f0r, PDBe:8f0r, PDBj:8f0r
PDBsum8f0r
PubMed36975198
UniProtD0E0C2|SCNA1_PERAM Sodium channel protein PaFPC1;
Q15858|SCN9A_HUMAN Sodium channel protein type 9 subunit alpha (Gene Name=SCN9A)

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