Structure of PDB 8ez2 Chain A

Receptor sequence
>8ez2A (length=890) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
EPKIHYRKDYKPSGFIINQVTLNINIHDQETIVRSVLDMDISKHNVGEDL
VFDGVGLKINEISINNKKLVEGEEYTYDNEFLTIFSKFVPKSKFAFSSEV
IIHPETNYALTGLYKSKNIIVSQCEATGFRRITFFIDRPDMMAKYDVTVT
ADKEKYPVLLSNGDKVNEFEIPGGRHGARFNDPPLKPCYLFAVVAGDLKH
LSATYITKYTKKKVELYVFSEEKYVSKLQWALECLKKSMAFDEDYFGLEY
DLSRLNLVAVSDFNVGAMENKGLNIFNANSLLASKKNSIDFSYARILTVV
GHEYFHQYTGNRVTLRDWFQLTLKEGLTVHRENLFSEEMTKTVTTRLSHV
DLLRSVQFLEDSSPLSHPIRPESYVSMENFYTTTVYDKGSEVMRMYLTIL
GEEYYKKGFDIYIKKNDGNTATCEDFNYAMEQAYKMKKADNSANLNQYLL
WFSQSGTPHVSFKYNYDAEKKQYSIHVNQYTKPDENQKEKKPLFIPISVG
LINPENGKEMISQTTLELTKESDTFVFNNIAVKPIPSLFRGFSAPVYIED
QLTDEERILLLKYDSDAFVRYNSCTNIYMKQILMNYNEFLKAKNEKLESF
QLTPVNAQFIDAIKYLLEDPHADAGFKSYIVSLPQDRYIINFVSNLDTDV
LADTKEYIYKQIGDKLNDVYYKMFKSLEAKADDLTYFNDESHVDFDQMNM
RTLRNTLLSLLSKAQYPNILNEIIEHSKSPYPSNWLTSLSVSAYFDKYFE
LYDKTYKLSKDDELLLQEWLKTVSRSDRKDIYEILKKLENEVLKDSKNPN
DIRAVYLPFTNNLRRFHDISGKGYKLIAEVITKTDKFNPMVATQLCEPFK
LWNKLDTKRQELMLNEMNTMLQEPQISNNLKEYLLRLTNK
3D structure
PDB8ez2 Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.
ChainA
Resolution1.83 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.4.11.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X68 A E319 V459 G460 A461 H496 E497 H500 E519 Y575 T576 Y580 E125 V265 G266 A267 H302 E303 H306 E325 Y381 T382 Y386
BS02 ZN A H496 H500 E519 H302 H306 E325
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8ez2, PDBe:8ez2, PDBj:8ez2
PDBsum8ez2
PubMed36634455
UniProtO96935|AMPN_PLAF7 Aminopeptidase N (Gene Name=M1AAP)

[Back to BioLiP]