Structure of PDB 8eym Chain A

Receptor sequence
>8eymA (length=319) Species: 318161 (Shewanella denitrificans OS217) [Search protein sequence]
TNTIMEQEARTAPQKIAEQLLANDAITESLGSVLREFKPKFVMIVGRGSS
DHAGVFAKYLFEIEASIPTFAAAPSVASVYGKTLKLAGGLVIVISQSGRS
PDILAQARMAKNAGAFCVALVNDETAPIKDIVDVVIPLRAGEEKAVAATK
SYLATLSALLQVAAKWTQNESLVEAVNSLPQALQAAVDAEPQLRAGSLTD
VKNLVVLGRGFGYAVSKEIALKLKEVCAIHAEAFSSAEFLHGPVTLVEKK
LSILDVCIRDESYGSHVEQIANVKQRGANLIHLHQTSADIHPRIAPLALL
QRFYIDVAAVAIALGINPD
3D structure
PDB8eym Substrate binding in the allosteric site mimics homotropic cooperativity in the SIS-fold glucosamine-6-phosphate deaminases.
ChainA
Resolution2.311 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.6.1.16: glutamine--fructose-6-phosphate transaminase (isomerizing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 16G A R50 D54 A74 A75 P77 S78 R47 D51 A71 A72 P74 S75
BS02 AGP A G51 S52 S98 Q99 A150 A151 K225 E228 G48 S49 S95 Q96 A147 A148 K222 E225
BS03 16G A Y62 R212 S238 E241 Y59 R209 S235 E238
Gene Ontology
Molecular Function
GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO:0008483 transaminase activity
GO:0097367 carbohydrate derivative binding
Biological Process
GO:1901135 carbohydrate derivative metabolic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:8eym, PDBe:8eym, PDBj:8eym
PDBsum8eym
PubMed37145875
UniProtQ12KP2

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