Structure of PDB 8exn Chain A

Receptor sequence
>8exnA (length=296) Species: 9606 (Homo sapiens) [Search protein sequence]
EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSP
FDHSRIKLHQNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQK
SRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYY
TVRQLELENLTTQETREILHFHYTTWPAFGVPESPASFLNFLFKVRESGS
LSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEM
RKFRMGLIATADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDL
3D structure
PDB8exn Structure guided studies of the interaction between PTP1B and JAK.
ChainA
Resolution2.151 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D48 V49 F182 A217 D47 V48 F179 A214
BS02 PO4 A A181 F182 G220 R221 Q266 A178 F179 G217 R218 Q263
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8exn, PDBe:8exn, PDBj:8exn
PDBsum8exn
PubMed37316570
UniProtP18031|PTN1_HUMAN Tyrosine-protein phosphatase non-receptor type 1 (Gene Name=PTPN1)

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