Structure of PDB 8ewa Chain A

Receptor sequence
>8ewaA (length=302) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
HHMRRIHFVGIGGAGMCGIAEVLLNLGYEVSGSDLKASAVTERLEKFGAQ
IFIGHQAENADGADVLVVSSAINRANPEVASALERRIPVVPRAEMLAELM
RYRHGIAVAGTHGKTTTTSLIASVFAAGGLDPTFVIGGRLNAAGTNAQLG
ASRYLVAEADESDASFLHLQPMVAVVTNIDADFNKLKKTFVEFLHNLPFY
GLAVMCVDDPVVREILPQIARPTVTYGLSEDADVRAINIRQEGMRTWFTV
LRPEREPLDVSVNMPGLHNVLNSLATIVIATDEGISDEAIVQGLSGFQGV
GR
3D structure
PDB8ewa Crystal Structure of UDP-N-acetylmuramate-L-alanine ligase (UDP-N-acetylmuramoyl-L-alanine synthetase, MurC) Pseudomonas aeruginosa in complex with ligand AZ-13644923
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.2.8: UDP-N-acetylmuramate--L-alanine ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WYI A H124 G125 T189 N190 D192 C226 Y246 H288 L291 N292 H112 G113 T177 N178 D180 C206 Y226 H268 L271 N272
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008763 UDP-N-acetylmuramate-L-alanine ligase activity
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0009058 biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ewa, PDBe:8ewa, PDBj:8ewa
PDBsum8ewa
PubMed
UniProtQ9HW02|MURC_PSEAE UDP-N-acetylmuramate--L-alanine ligase (Gene Name=murC)

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