Structure of PDB 8eve Chain A

Receptor sequence

>8eveA (length=424) Species: 9606 (Homo sapiens)

MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAV
SYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVM
EIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGL
PQVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIERET
GFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSL
GGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHD
PVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRND
NDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNT
SGIQTEWSPPLTMLFLCATKFSAS

3D structure

• PDB: 8eve The peroxidation-derived DNA adduct, 6-oxo-M 1 dG, is a strong block to replication by human DNA polymerase eta.
• Chain: A
• Resolution: 2.35 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Q38 Y39 W42 R61 K86 R93 K293 K311 R313 P316 K317 T318 I319 G320 C321 S322 K323 N324 P326 R351	Q38 Y39 W42 R61 K86 R93 K285 K303 R305 P308 K309 T310 I311 G312 C313 S314 K315 N316 P318 R343
BS02	dna	A	S113 D115 K224 S257 G259 G260 K261 L262 R377 L381 R382 R383 C384	S113 D115 K216 S249 G251 G252 K253 L254 R369 L373 R374 R375 C376
BS03	CA	A	C227 N230 R234 Q235 T236	C219 N222 R226 Q227 T228
BS04	CA	A	R61 S62	R61 S62

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:8eve, PDBe:8eve, PDBj:8eve
• PDBsum: 8eve
• PubMed: 37468099
• UniProt: Q9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)