Structure of PDB 8eua Chain A

Receptor sequence
>8euaA (length=311) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
RTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEG
KTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLT
SIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALIL
AYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGV
EAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSAPPAQYE
LKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITD
VFYKENSYTTT
3D structure
PDB8eua Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WUK A W106 N109 C111 L162 G163 D164 P248 Y264 Y268 Q269 G271 H272 W104 N107 C109 L160 G161 D162 P246 Y262 Y266 Q267 G269 H270
BS02 ZN A C189 C192 C224 C187 C190 C222
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8eua, PDBe:8eua, PDBj:8eua
PDBsum8eua
PubMed36977673
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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