Structure of PDB 8ero Chain A

Receptor sequence
>8eroA (length=364) Species: 8355 (Xenopus laevis) [Search protein sequence]
PLSAQQLKKLEEHKYSASGRSLVEPPMQVYWNWLVEKVPLWLAPNTITMV
GLLLNVLSTLILVCYCPTATEGAPFWTYLLCAIGLFVYQSLDAIDGKQAR
RTNSSSPLGEMFDHGCDSISIVFVNLGTIAAVRLGTLPGWMFYCCFVGMF
MFYCAQWQTYVCGTLKFGIIDVTELQISVTVMFLMTAVCGPELWDYEIPF
TGLPMKTIPLLGIIGGTVYSCSNYFRVILSGGVGKNGSTVAGTSVLSPGL
HIGLVLLLALMIYKKSTTNLFLQNPCLYTLAFGFVSAKITIKLVIAHMTK
SEISLQDTAFIGPGLLFFNQYFNSFIDEYIVLWIAMVISFADLLRYCISV
CLQIATHLRISVFR
3D structure
PDB8ero Substrate recognition and catalysis in eukaryotic cholinephosphotransferase-1
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.8.2: diacylglycerol cholinephosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D111 D132 D136 D92 D113 D117
BS02 MG A D111 D132 D92 D113
BS03 LBN A Q325 D326 G333 F337 F344 Q306 D307 G314 F318 F325
BS04 LBN A L79 M355 L60 M336
BS05 LBN A W352 I353 V356 W333 I334 V337
BS06 CDP A Y34 P63 N64 D111 G115 A118 R119 G128 Y15 P44 N45 D92 G96 A99 R100 G109
Gene Ontology
Molecular Function
GO:0004142 diacylglycerol cholinephosphotransferase activity
GO:0016740 transferase activity
GO:0016780 phosphotransferase activity, for other substituted phosphate groups
GO:0046872 metal ion binding
Biological Process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0006657 CDP-choline pathway
GO:0008654 phospholipid biosynthetic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8ero, PDBe:8ero, PDBj:8ero
PDBsum8ero
PubMed37179328
UniProtQ4KLV1|CHPT1_XENLA Cholinephosphotransferase 1 (Gene Name=chpt1)

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