Structure of PDB 8eq5 Chain A

Receptor sequence
>8eq5A (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
EIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYA
MKVLKKATLKVRDRVRLVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDL
FTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEG
HIKLTDFGLSKESHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVL
MFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNP
ANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKP
3D structure
PDB8eq5 The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K284 L285 M287 R300 F303 K304 R305 N306 N309 K227 L228 M230 R243 F246 K247 R248 N249 N252
BS02 QCT A F79 K100 V131 L147 D148 L155 E197 L200 L214 F31 K52 V76 L92 D93 L100 E142 L145 L159
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8eq5, PDBe:8eq5, PDBj:8eq5
PDBsum8eq5
PubMed37149146
UniProtP51812|KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 (Gene Name=RPS6KA3)

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