Structure of PDB 8epr Chain A

Receptor sequence
>8eprA (length=763) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence]
SEIGRLNNQSLLWGPYRPNIYFGTRPRIGKSLMTGLMWGKIESYTDFQHT
VRYTCEQNEGMKGYGWDEYDPRRGGIQSIHDIQNGLDITTSFVKIPGGAH
GGSWAARIKGTLNDDAPKDQKTIVVFYVSQEGENSELEAVPSENEFGYEG
DVILKGRSEALGNYKLVVTKGKGVIPQSDHDLSRLRGPGQTVVQSLTYPD
EVLWQAKPILFQQLKAGIDWLVENKYDVADPPPPWQVYLLANKPGSGNVH
IVQKVFEGDFEFDILFSSESAGKEVTSKDLEREVKQATEVFGERFARVFD
LKAPFQGDNYKKFGKSMFSNLIGGIGYFYGHSLVDRSYAPEYDEENEGFW
EDAAEARARHQEALEGPYELFTSIPSRPFFPRGFLWDEGFHLLPIADWDI
DLALEIIKSWYNLMDEDGWIAREQILGAEARSKVPKEFQTQYPHYANPPT
LFLVLDNFVERLRKLDETLSTASVDNPEVGLEYLRRLYPLLRRQFDWFRK
TQAGDIKSYDREAYSTKEAYRWRGRTVSHCLTSGLDDYPRPQPPHPGELH
VDLMSWVGVMVKSLISIGSLLGATEDVEFYTKVLDAIEHNLDDLHWSEKE
GCYCDATIDEFEEHKLVCHKGYISLFPFLTGLLKPDSPKLGKLLALIGDE
SELWSPYGLRSLSKKDEFYGTAENYWRSPVWININYLAIVQLYNIATQDG
PYKETARDLYTRLRKNIVETVYRNWEETGFAWEQYNPETGKGQRTQHFTG
WTSLVVKIMSGHH
3D structure
PDB8epr Structure-Based Design of Potent Iminosugar Inhibitors of Endoplasmic Reticulum alpha-Glucosidase I with Anti-SARS-CoV-2 Activity.
ChainA
Resolution1.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.106: mannosyl-oligosaccharide glucosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WSW A P412 F417 F421 W423 D424 G584 D586 Y725 R794 F798 P375 F380 F384 W386 D387 G534 D536 Y675 R744 F748
Gene Ontology
Molecular Function
GO:0004573 Glc3Man9GlcNAc2 oligosaccharide glucosidase activity
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006487 protein N-linked glycosylation
GO:0009311 oligosaccharide metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8epr, PDBe:8epr, PDBj:8epr
PDBsum8epr
PubMed36762932
UniProtG0SFD1

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