Structure of PDB 8epm Chain A

Receptor sequence

>8epmA (length=991) Species: 9606 (Homo sapiens)

PPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFE
AGIKIVALGNGWNVMDFIVVLSGILATAGLRTLRAVRVLRPLKLVSGIPS
LQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNS
GILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCI
TMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAK
VKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLE
MSLKFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKY
WASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGT
PSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIV
LTLFGNYTLLNVFLAIAVDNLANAQFEMCILLVIAASSIALAAEDPVLTN
SERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILLWNILDFVVVVGALVAF
ALANRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILI
VYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKNKMEVK
GREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRS
NRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQVVSPSFEYTIMAMIA
LNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFR
DTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQ
GYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESH
INRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQN
ENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLT

3D structure

• PDB: 8epm Structures of the R-type human Ca v 2.3 channel reveal conformational crosstalk of the intracellular segments.
• Chain: A
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	E309 E657 E1372	E203 E422 E678

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0005245 voltage-gated calcium channel activity
• GO:0005262 calcium channel activity
• GO:0005509 calcium ion binding
• GO:0008331 high voltage-gated calcium channel activity
• GO:0022843 voltage-gated monoatomic cation channel activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0006816 calcium ion transport
• GO:0007268 chemical synaptic transmission
• GO:0055085 transmembrane transport
• GO:0070588 calcium ion transmembrane transport
• GO:0098703 calcium ion import across plasma membrane

Cellular Component

• GO:0005886 plasma membrane
• GO:0005891 voltage-gated calcium channel complex
• GO:0016020 membrane
• GO:0034702 monoatomic ion channel complex
• GO:0043025 neuronal cell body
• GO:0045202 synapse

External links

• PDB: RCSB:8epm, PDBe:8epm, PDBj:8epm
• PDBsum: 8epm
• PubMed: 36446785
• UniProt: Q15878|CAC1E_HUMAN Voltage-dependent R-type calcium channel subunit alpha-1E (Gene Name=CACNA1E)