Structure of PDB 8eop Chain A

Receptor sequence
>8eopA (length=1687) Species: 9606 (Homo sapiens) [Search protein sequence]
AFWTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEH
HECHFPNKPLPSAGTVPWLQGLICNVNNTCFPQLTPGEEPGRLSNFNDSL
VSRLLADARTVLGGASAHRTLAGLGSLLEAAEDLAQELLALRSLVELRAL
LQRPRGTSGPLELLSEALCSVSPACSELIGALDSHPLSRLLWRRLKPLIL
GKLLFAPDTPFTRKLMAQVNRTFEELTLLRDVREVWEMLGPRIFTFMNDS
SNVAMLQRLLQMALRSFLDPGSGGYSWQDAHADVGHLVGTLGRVTECLSL
DKLEAAPSEAALVSRALQLLAEHRFWAGVVFLGPETPDLGPGHVRIKIRM
DIDVVTRTNKIRDRFWDPGPAADPLTDLRYVWGGFVYLQDLVERAAVRVL
SGANPRAGLYLQQMPYPCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTVKA
VVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGD
ILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLY
LPYVLCVAWRDRLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHN
VGTRPTADVFSLAQVSGLLLLDAALYGLATWYLEAVCPGQYGIPEPSPGV
SVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGL
FPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGR
LKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGG
SQVVILDQPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDR
VAVVAGGRLCCCGSPLFLRRLEEIFLKVVEECAGRVQGWALTRQQLQALL
LKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVPPFGHYPALRLSPTM
YGAQVSFFSEDAPGDPGRARLLEALLQEAGLEEPPVQHSSHRFSAPEVPA
EVAKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTGS
GEVVQNLTGRNLSDFLVKTYPRLVRQGLKTKKWVNEVRYGGFSLGGRDPG
LPSGQELGRSVEELWALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWF
NNKGWHSMVAFVNRASNAILRAHLPPGPARHAHSITTLNHPLNLTKEQLS
EGALMASSVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLS
PTLYWLGNFLWDMCNYLVPACIVVLIFLAFQQRAYVAPANLPALLLLLLL
YGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFVLELFSDQ
KLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQSPL
RWEVVGKNLLAMVIQGPLFLLFTLLLQHRSQDEDVARERERVVQGATQGD
VLVLRNLTKVYRGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVT
GDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELL
ARLRGVPEAQVAQTAGSGLARLGLSWYADRPAGTYSGGNKRKLATALALV
GDPAVVFLDQPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEAL
CSRLAIMVNGRFRCLGSPQHLKGRFLEEVFLYFSKDQ
3D structure
PDB8eop Cryo-EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms.
ChainA
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.6.2.1: P-type phospholipid transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A H939 S941 Y1802 N1829 G1830 G1832 K1833 S1835 Q1874 H782 S784 Y1461 N1488 G1489 G1491 K1492 S1494 Q1533
BS02 MG A T1834 Q1874 T1493 Q1533
BS03 ATP A F816 S819 A823 N843 G844 G846 K847 T848 T849 T1925 S1927 F659 S662 A666 N686 G687 G689 K690 T691 T692 T1584 S1586
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0005548 phospholipid transporter activity
GO:0016887 ATP hydrolysis activity
GO:0034188 apolipoprotein A-I receptor activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0090554 phosphatidylcholine floppase activity
GO:0090556 phosphatidylserine floppase activity
GO:0140326 ATPase-coupled intramembrane lipid transporter activity
GO:0140328 floppase activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006869 lipid transport
GO:0006909 phagocytosis
GO:0007613 memory
GO:0008542 visual learning
GO:0010875 positive regulation of cholesterol efflux
GO:0018149 peptide cross-linking
GO:0019216 regulation of lipid metabolic process
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034205 amyloid-beta formation
GO:0034380 high-density lipoprotein particle assembly
GO:0034504 protein localization to nucleus
GO:0038027 apolipoprotein A-I-mediated signaling pathway
GO:0042985 negative regulation of amyloid precursor protein biosynthetic process
GO:0043409 negative regulation of MAPK cascade
GO:0044857 plasma membrane raft organization
GO:0045332 phospholipid translocation
GO:0045806 negative regulation of endocytosis
GO:0050766 positive regulation of phagocytosis
GO:0055085 transmembrane transport
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0150094 amyloid-beta clearance by cellular catabolic process
GO:1900223 positive regulation of amyloid-beta clearance
GO:1901076 positive regulation of engulfment of apoptotic cell
GO:1902430 negative regulation of amyloid-beta formation
GO:1902991 regulation of amyloid precursor protein catabolic process
GO:1902995 positive regulation of phospholipid efflux
GO:1903898 negative regulation of PERK-mediated unfolded protein response
GO:2000010 positive regulation of protein localization to cell surface
Cellular Component
GO:0000139 Golgi membrane
GO:0001891 phagocytic cup
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0030054 cell junction
GO:0031901 early endosome membrane
GO:0032587 ruffle membrane
GO:0042995 cell projection
GO:0043231 intracellular membrane-bounded organelle
GO:0097386 glial cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8eop, PDBe:8eop, PDBj:8eop
PDBsum8eop
PubMed36484366
UniProtQ8IZY2|ABCA7_HUMAN Phospholipid-transporting ATPase ABCA7 (Gene Name=ABCA7)

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