Structure of PDB 8emw Chain A

Receptor sequence
>8emwA (length=743) Species: 9606 (Homo sapiens) [Search protein sequence]
LEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNMEVD
TLDISSIRDTRTGRYARLPKDPKIREVLGFARLEEKLMTVVSGPDPVNTV
FLNFMAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQ
DGRIPVKNILKMFSADKKRVETALESCGLKFNRSESIRPDEFSLEIFERF
LNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPP
LRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLS
TDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVW
KGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHV
DSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVK
NKKRDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNKCFEMSSFV
ETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQL
VALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVD
GIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNS
FNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYH
YVCLRNEANQPLCLPALLIYTEASDYIPSLMDQRARQLAALIG
3D structure
PDB8emw G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface.
ChainA
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.11: phosphoinositide phospholipase C.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A N333 D364 E413 N317 D348 E397
Gene Ontology
Molecular Function
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004629 phospholipase C activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0008081 phosphoric diester hydrolase activity
GO:0016787 hydrolase activity
GO:0045296 cadherin binding
GO:0060090 molecular adaptor activity
GO:0140677 molecular function activator activity
Biological Process
GO:0003073 regulation of systemic arterial blood pressure
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007208 phospholipase C-activating serotonin receptor signaling pathway
GO:0016042 lipid catabolic process
GO:0035556 intracellular signal transduction
GO:0046488 phosphatidylinositol metabolic process
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051209 release of sequestered calcium ion into cytosol
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0099524 postsynaptic cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8emw, PDBe:8emw, PDBj:8emw
PDBsum8emw
PubMed37172014
UniProtQ01970|PLCB3_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (Gene Name=PLCB3)

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