Structure of PDB 8em8 Chain A

Receptor sequence
>8em8A (length=779) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
EDSLMEDHLELREKLSEDIDMIKTSLKNNLVCSTLNDNEILTLSNYMQFF
VFIKQGEKGSYFFIINSGKFDVYVNDKKVKTMGKGSSFGEAALIHNTQRS
ATIIAETTLWGVQRSTFRATLKQLSNRNFNENRTFIDSVSVFDMLTEAQK
NMITNACVIQNFKSGETIVKQGDYGDVLYILKEGKATVYINDEEIRVLEK
GSYFGERALLYDEPRSATIIAKEPTACASICRKLLNIVLGNLQVVLFRNI
MTEALQQSEIFKQFSGDQLNDLADTAIVRDYPANYNILHKDKVKSVKYII
VLEGKVELFLDDTSIGILSRGMSFGDQYVLNQKQPFKHTIKSLEVCKIAL
ITETCLADCLGNNNIDASIDYNNKKSIIKKMYIFRYLTDKQCNLLIEAFR
TTRYEEGDYIIQEGEVGSRFYIIKNGEVEIVKNKKRLRTLGKNDYFGERA
LLYDEPRTASVISKVNNVECWFVDKSVFLQIIQGPMLAHLEERIKMQDTK
VEMDELETERIIGRGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKL
EREITAENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSK
SQAQFYLGSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKK
VQGRAYTLVGTPHYMAPEVILGKGYGCTVDIWALGICLYEFICGPLPFGN
DEEDQLEIFRDILTGQLTFPDYVTDTDSINLMKRLLCRLPQGRIGCSING
FKDIKDHPFFSNFNWDKLAGRLLDPPLVS
3D structure
PDB8em8 Co-crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium falciparum in complex with RY-1-165
ChainA
Resolution2.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.12: cGMP-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WLK A I547 A568 K570 T618 V621 T622 G624 L671 I512 A530 K532 T580 V583 T584 G586 L633
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004691 cAMP-dependent protein kinase activity
GO:0004692 cGMP-dependent protein kinase activity
GO:0005524 ATP binding
GO:0030553 cGMP binding
GO:0046872 metal ion binding
GO:0106310 protein serine kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007276 gamete generation
GO:0010737 protein kinase A signaling
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005952 cAMP-dependent protein kinase complex
GO:0016020 membrane
GO:0019898 extrinsic component of membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8em8, PDBe:8em8, PDBj:8em8
PDBsum8em8
PubMed38372781
UniProtQ8I719|KGP_PLAF7 cGMP-dependent protein kinase (Gene Name=PKG)

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