Structure of PDB 8elc Chain A
Receptor sequence
>8elcA (length=355) Species:
9606
(Homo sapiens) [
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QFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLS
RPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVM
ELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV
VKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDI
WSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRN
YVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDK
RISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYK
EVMDW
3D structure
PDB
8elc
Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1.
Chain
A
Resolution
2.072 Å
3D
structure
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Enzymatic activity
Enzyme Commision number
2.7.11.24
: mitogen-activated protein kinase.
Interaction with ligand
Site
#
Ligand
Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01
Y56
A
I32 G35 V40 A53 K55 L106 M108 M111 N114 C116 Q117 L168 Y185
I24 G27 V32 A45 K47 L98 M100 M103 N106 C108 Q109 L160 Y177
Gene Ontology
Molecular Function
GO:0004672
protein kinase activity
GO:0004674
protein serine/threonine kinase activity
GO:0004705
JUN kinase activity
GO:0004707
MAP kinase activity
GO:0004712
protein serine/threonine/tyrosine kinase activity
GO:0005515
protein binding
GO:0005524
ATP binding
GO:0106310
protein serine kinase activity
Biological Process
GO:0000165
MAPK cascade
GO:0006468
protein phosphorylation
GO:0007254
JNK cascade
GO:0010628
positive regulation of gene expression
GO:0010744
positive regulation of macrophage derived foam cell differentiation
GO:0016310
phosphorylation
GO:0031398
positive regulation of protein ubiquitination
GO:0032436
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033554
cellular response to stress
GO:0034614
cellular response to reactive oxygen species
GO:0038095
Fc-epsilon receptor signaling pathway
GO:0042752
regulation of circadian rhythm
GO:0046686
response to cadmium ion
GO:0048511
rhythmic process
GO:0050804
modulation of chemical synaptic transmission
GO:0061833
protein localization to tricellular tight junction
GO:0071803
positive regulation of podosome assembly
GO:0090398
cellular senescence
GO:0090594
inflammatory response to wounding
GO:0097190
apoptotic signaling pathway
GO:1900017
positive regulation of cytokine production involved in inflammatory response
GO:2001235
positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005634
nucleus
GO:0005654
nucleoplasm
GO:0005737
cytoplasm
GO:0005739
mitochondrion
GO:0005829
cytosol
GO:0005886
plasma membrane
GO:0016607
nuclear speck
GO:0098685
Schaffer collateral - CA1 synapse
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:8elc
,
PDBe:8elc
,
PDBj:8elc
PDBsum
8elc
PubMed
36826833
UniProt
P45984
|MK09_HUMAN Mitogen-activated protein kinase 9 (Gene Name=MAPK9)
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