Structure of PDB 8el1 Chain A

Receptor sequence

>8el1A (length=512) Species: 9606,83333 [Search protein sequence]

GKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATG
DGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLI
AYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEP
YFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHM
NADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQP
SKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVAL
KSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGR
QTVDEALKDAQTGSELYRQSLEIISRYLREQATGAADTAPMGASGATSRK
ALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGV
TNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVK
QRGWDGFVEFFH

3D structure

PDB

8el1 Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models, associated with cardiac troponin increases in patients

Chain

Resolution

2.406 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GLC	A	D-182 K-181 E-85 Y-41 W34	D10 K11 E107 Y151 W226
BS02	GLC	A	W-134 D-131 R-130 E-43 P-42 Y-41 W144	W58 D61 R62 E149 P150 Y151 W336
BS03	WME	A	R215 H224 A227 F228 M231 K234 V249 M250 V253 G262 R263 T266 F270 F319	R407 H416 A419 F420 M423 K426 V441 M442 V445 G454 R455 T458 F462 F511

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0015144	carbohydrate transmembrane transporter activity
GO:1901982	maltose binding

	Biological Process
GO:0006974	DNA damage response
GO:0008643	carbohydrate transport
GO:0015768	maltose transport
GO:0034219	carbohydrate transmembrane transport
GO:0034289	detection of maltose stimulus
GO:0042956	maltodextrin transmembrane transport
GO:0042981	regulation of apoptotic process
GO:0055085	transmembrane transport
GO:0060326	cell chemotaxis

	Cellular Component
GO:0016020	membrane
GO:0030288	outer membrane-bounded periplasmic space
GO:0042597	periplasmic space
GO:0043190	ATP-binding cassette (ABC) transporter complex
GO:0055052	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060	maltose transport complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8el1, PDBe:8el1, PDBj:8el1
PDBsum	8el1
PubMed	37880389
UniProt	P0AEX9\|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE); Q07820\|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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