Structure of PDB 8el0 Chain A

Receptor sequence

>8el0A (length=516) Species: 9606,83333 [Search protein sequence]

KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQV
AATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYN
GKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFN
LQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIK
NKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTF
KGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLG
AVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINA
ASGRQTVDEALKDAQTGSELYRQSLEIISRYLREQATGAADTAPMGASGA
TSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVF
SDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRD
WLVKQRGWDGFVEFFH

3D structure

PDB

8el0 Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models, associated with cardiac troponin increases in patients

Chain

Resolution

1.917 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GLC	A	D-182 K-181 E-85 Y-41 W34	D14 K15 E111 Y155 W230
BS02	GLC	A	W-134 D-131 R-130 E-43 P-42 Y-41 W144 R148	W62 D65 R66 E153 P154 Y155 W340 R344
BS03	WLW	A	V216 V220 H224 F228 M231 L235 V249 M250 V253 F254 G262 R263 T266 L267 F270	V412 V416 H420 F424 M427 L431 V445 M446 V449 F450 G458 R459 T462 L463 F466

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0015144	carbohydrate transmembrane transporter activity
GO:1901982	maltose binding

	Biological Process
GO:0006974	DNA damage response
GO:0008643	carbohydrate transport
GO:0015768	maltose transport
GO:0034219	carbohydrate transmembrane transport
GO:0034289	detection of maltose stimulus
GO:0042956	maltodextrin transmembrane transport
GO:0042981	regulation of apoptotic process
GO:0055085	transmembrane transport
GO:0060326	cell chemotaxis

	Cellular Component
GO:0016020	membrane
GO:0030288	outer membrane-bounded periplasmic space
GO:0042597	periplasmic space
GO:0043190	ATP-binding cassette (ABC) transporter complex
GO:0055052	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060	maltose transport complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8el0, PDBe:8el0, PDBj:8el0
PDBsum	8el0
PubMed	37880389
UniProt	P0AEX9\|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE); Q07820\|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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