Structure of PDB 8ej4 Chain A

Receptor sequence
>8ej4A (length=850) Species: 9606 (Homo sapiens) [Search protein sequence]
KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQE
REQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGK
TILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPD
PNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILL
SSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF
FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSL
AQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKI
LFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAM
YYLLEELKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEK
KLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQ
RAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHTSSFCRGLF
SVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH
ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWL
VSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC
NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCE
GLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDL
GVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEP
3D structure
PDB8ej4 Cryo-EM structures of the active NLRP3 inflammasome disc.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS A R154 Y168 T169 A228 G229 G231 K232 T233 I234 R351 F373 Y381 R22 Y36 T37 A96 G97 G99 K100 T101 I102 R219 F241 Y249
BS02 MG A K232 T233 D302 K100 T101 D170
External links
PDB RCSB:8ej4, PDBe:8ej4, PDBj:8ej4
PDBsum8ej4
PubMed36442502
UniProtQ96P20|NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 (Gene Name=NLRP3)

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