Structure of PDB 8eij Chain A

Receptor sequence
>8eijA (length=430) Species: 9606 (Homo sapiens) [Search protein sequence]
QSREQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLE
LFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAA
EAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAPKLY
PAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVG
TVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGL
YEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFL
ECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNR
IAKLKKVQTITTKSLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGR
GARQKLLGRSWSVPVIRHLFAPLKDYFACE
3D structure
PDB8eij Cryo-EM structure of human DNMT3B homo-trimer
ChainA
Resolution3.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A F581 D582 S604 D627 V628 R832 W834 F167 D168 S190 D213 V214 R409 W411
BS02 ZN A C438 C455 C458 C24 C41 C44
BS03 ZN A C478 C481 C500 C64 C67 C86
BS04 ZN A C490 C495 C76 C81
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0009008 DNA-methyltransferase activity
Biological Process
GO:0010468 regulation of gene expression

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Molecular Function
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Biological Process
External links
PDB RCSB:8eij, PDBe:8eij, PDBj:8eij
PDBsum8eij
PubMed37941146
UniProtQ9UBC3|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)

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