Structure of PDB 8eii Chain A

Receptor sequence
>8eiiA (length=431) Species: 9606 (Homo sapiens) [Search protein sequence]
DQSREQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFL
ELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTA
AEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAPKL
YPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAV
GTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKG
LYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRF
LECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYN
RIAKLKKVQTITTKSLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMG
RGARQKLLGRSWSVPVIRHLFAPLKDYFACE
3D structure
PDB8eii Cryo-EM structure of human DNMT3B homo-tetramer (form II)
ChainA
Resolution3.12 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A F581 G583 T586 S604 E605 V606 D627 V628 S833 F168 G170 T173 S191 E192 V193 D214 V215 S411
BS02 ZN A C438 C458 C25 C45
BS03 ZN A C478 C481 C500 C65 C68 C87
BS04 ZN A C490 C495 C524 C77 C82 C111
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0009008 DNA-methyltransferase activity
Biological Process
GO:0010468 regulation of gene expression

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Molecular Function
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Biological Process
External links
PDB RCSB:8eii, PDBe:8eii, PDBj:8eii
PDBsum8eii
PubMed37941146
UniProtQ9UBC3|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)

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