Structure of PDB 8ei8 Chain A

Receptor sequence
>8ei8A (length=374) Species: 9606 (Homo sapiens) [Search protein sequence]
DRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLR
RRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQI
NPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTL
KDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGG
ESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFD
EKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKR
IRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNR
LDLPPYKSYEQLREKLLYAIEETE
3D structure
PDB8ei8 Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F495 R496 Y499 R561 E562 F565 K620 F621 C750 M752 Q753 E789 F4 R5 Y8 R70 E71 F74 K129 F130 C259 M261 Q262 E298
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity

View graph for
Molecular Function
External links
PDB RCSB:8ei8, PDBe:8ei8, PDBj:8ei8
PDBsum8ei8
PubMed37914719
UniProtO00308|WWP2_HUMAN NEDD4-like E3 ubiquitin-protein ligase WWP2 (Gene Name=WWP2)

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