Structure of PDB 8ei6 Chain A

Receptor sequence
>8ei6A (length=367) Species: 9606 (Homo sapiens) [Search protein sequence]
DRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLR
RRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQI
NPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTL
KDLESIDPEFYNSIVWIKENNLYFIQDMEILGKVTTHELKEGGESIRVTE
ENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELM
LCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFV
TGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYK
SYEQLREKLLYAIEETE
3D structure
PDB8ei6 Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides
ChainA
Resolution3.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y499 H500 R503 F504 H507 G619 Y8 H9 R12 F13 H16 G128
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity

View graph for
Molecular Function
External links
PDB RCSB:8ei6, PDBe:8ei6, PDBj:8ei6
PDBsum8ei6
PubMed37914719
UniProtO00308|WWP2_HUMAN NEDD4-like E3 ubiquitin-protein ligase WWP2 (Gene Name=WWP2)

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