Structure of PDB 8ei4 Chain A

Receptor sequence
>8ei4A (length=365) Species: 9606 (Homo sapiens) [Search protein sequence]
HMGFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLR
RRLYVIFDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNLQINPASTINPD
HLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTE
FYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEEN
KDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLC
GMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTG
TCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSY
EQLKEKLLFAIEETE
3D structure
PDB8ei4 Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides
ChainA
Resolution2.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E702 F703 S706 W709 C718 L720 M722 M760 E150 F151 S154 W157 C166 L168 M170 M208
BS02 WHL A L720 E721 L168 E169
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity

View graph for
Molecular Function
External links
PDB RCSB:8ei4, PDBe:8ei4, PDBj:8ei4
PDBsum8ei4
PubMed37914719
UniProtQ9H0M0|WWP1_HUMAN NEDD4-like E3 ubiquitin-protein ligase WWP1 (Gene Name=WWP1)

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