Structure of PDB 8ei2 Chain A

Receptor sequence
>8ei2A (length=358) Species: 9606 (Homo sapiens) [Search protein sequence]
GSLQFEDKWDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGPAK
IHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKP
FCQLEITLMNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLG
EAFDSQLVIGVRESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAP
SYLQQNGVQNYMKYADAKLKEEEKRALRYLETRRECNSVEALMECCVNAL
VTSFKETILAECQGMIKRNETEKLHLMFSLMDKVPNGIEPMLKDLEEHII
SAGLADMVAAAETITTDSEKYREQLDTLFNRFSKLVKEAFQDDPRFLTAR
DKAYKAVV
3D structure
PDB8ei2 Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A W40 F41 F44 H48 K109 Q113 W30 F31 F34 H38 K99 Q103
Gene Ontology
Molecular Function
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ei2, PDBe:8ei2, PDBj:8ei2
PDBsum8ei2
PubMed37914719
UniProtQ93034|CUL5_HUMAN Cullin-5 (Gene Name=CUL5)

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