Structure of PDB 8ei1 Chain A

Receptor sequence
>8ei1A (length=344) Species: 9606 (Homo sapiens) [Search protein sequence]
DETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQI
CEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRT
YVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAI
DRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEY
LHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNN
LLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDK
TMRQELDDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPN
3D structure
PDB8ei1 Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides
ChainA
Resolution2.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V488 P491 M497 R498 L501 D502 K505 K527 F530 F533 I534 R537 P538 V293 P296 M302 R303 L306 D307 K310 K332 F335 F338 I339 R342 P343
Gene Ontology
Molecular Function
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ei1, PDBe:8ei1, PDBj:8ei1
PDBsum8ei1
PubMed37914719
UniProtQ13620|CUL4B_HUMAN Cullin-4B (Gene Name=CUL4B)

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