Structure of PDB 8ei0 Chain A

Receptor sequence
>8ei0A (length=132) Species: 9606 (Homo sapiens) [Search protein sequence]
GASPSAQELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALCY
LKMQQHEQALADCRRALELDGQSVKAHFFLGQCQLEMESYDEAIANLQRA
YSLAKEQRLNFGDDIPSALRIAKKKRWNSIEE
3D structure
PDB8ei0 Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides
ChainA
Resolution1.47 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A N34 F37 L68 K95 F98 F99 Q102 F131 D134 N14 F17 L48 K75 F78 F79 Q82 F111 D114
BS02 WHL A F131 D134 F111 D114
External links
PDB RCSB:8ei0, PDBe:8ei0, PDBj:8ei0
PDBsum8ei0
PubMed37914719
UniProtQ9UNE7|CHIP_HUMAN E3 ubiquitin-protein ligase CHIP (Gene Name=STUB1)

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