Structure of PDB 8egq Chain A

Receptor sequence

>8egqA (length=324) Species: 10116 (Rattus norvegicus) [Search protein sequence]

QSAIDVVAEKPSVRLTPTMMLYSGDGSHLLKSGRYLQQELPVRIAHRIKG
FRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQL
LDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHL
ALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHV
AARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVD
LIIRISDRGGGIAHKDLDRVMDYHFTTAESGPMHGFGFGLPTSRAYAEYL
GGSLQLQSLQGIGTDVYLRLRHID

3D structure

PDB

8egq Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors.

Chain

Resolution

1.955 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.4: [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ADP	A	E245 N249 R252 A253 I290 V298 T304 T305 G335 G337 G339 L340	E217 N221 R224 A225 I262 V270 T276 T277 G285 G287 G289 L290
BS02	WJK	A	I72 Y99 A102 L128 H132 K133 R167 I170 R171 G331	I44 Y71 A74 L100 H104 K105 R139 I142 R143 G281
BS03	WJK	A	R39 M45 R71 G169 M172 L173 I235 L350	R14 M20 R43 G141 M144 L145 I207 L300

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0047323	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
GO:0106310	protein serine kinase activity

	Biological Process
GO:0006550	isoleucine catabolic process
GO:0006552	L-leucine catabolic process
GO:0006574	valine catabolic process
GO:0007283	spermatogenesis
GO:0008610	lipid biosynthetic process
GO:0009083	branched-chain amino acid catabolic process
GO:0010906	regulation of glucose metabolic process
GO:0016310	phosphorylation

	Cellular Component
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0045252	oxoglutarate dehydrogenase complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8egq, PDBe:8egq, PDBj:8egq
PDBsum	8egq
PubMed	36717078
UniProt	Q00972\|BCKD_RAT Branched-chain alpha-ketoacid dehydrogenase kinase (Gene Name=Bckdk)

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