Structure of PDB 8egf Chain A

Receptor sequence
>8egfA (length=325) Species: 10116 (Rattus norvegicus) [Search protein sequence]
NQSAIDVVAEKPSVRLTPTMMLYSGDGSHLLKSGRYLQQELPVRIAHRIK
GFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQ
LLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHH
LALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGH
VAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDV
DLIIRISDRGGGIAHKDLDRVMDYHFTTAESGPMHGFGFGLPTSRAYAEY
LGGSLQLQSLQGIGTDVYLRLRHID
3D structure
PDB8egf Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.4: [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A E245 N249 R252 A253 G289 I290 T304 T305 G335 G337 G339 L340 E218 N222 R225 A226 G262 I263 T277 T278 G286 G288 G290 L291
BS02 WIK A R39 M45 R71 M172 L173 I235 Y349 R15 M21 R44 M145 L146 I208 Y300
BS03 WIK A L129 R167 R171 G331 P332 L102 R140 R144 G282 P283
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0047323 [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
GO:0106310 protein serine kinase activity
Biological Process
GO:0006550 isoleucine catabolic process
GO:0006552 L-leucine catabolic process
GO:0006574 valine catabolic process
GO:0007283 spermatogenesis
GO:0008610 lipid biosynthetic process
GO:0009083 branched-chain amino acid catabolic process
GO:0010906 regulation of glucose metabolic process
GO:0016310 phosphorylation
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0045252 oxoglutarate dehydrogenase complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:8egf, PDBe:8egf, PDBj:8egf
PDBsum8egf
PubMed36717078
UniProtQ00972|BCKD_RAT Branched-chain alpha-ketoacid dehydrogenase kinase (Gene Name=Bckdk)

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