Structure of PDB 8efh Chain A

Receptor sequence
>8efhA (length=734) Species: 9606 (Homo sapiens) [Search protein sequence]
MAVFGAAAPYLRKSEKERLEAQTRPFDLKKDVFVPDDKQEFVKAKIVSRE
GGKVTAETEYGKTVTVKEDQVMQQNPPKFDKIEDMAMLTFLHEPAVLYNL
KDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIF
SISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVLEDQIIQA
NPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRV
IFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASI
DDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQA
EPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYA
TGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSF
EQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDL
IEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKP
EAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFAN
KKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPL
VMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPASRKGAEKLLS
SLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERL
3D structure
PDB8efh Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin.
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T185 E228 S242 T180 E205 S219
BS02 ADP A N126 P127 G181 G183 K184 T185 V186 N238 N240 N121 P122 G176 G178 K179 T180 V181 N215 N217
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

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Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8efh, PDBe:8efh, PDBj:8efh
PDBsum8efh
PubMed36633586
UniProtP12883|MYH7_HUMAN Myosin-7 (Gene Name=MYH7)

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