Structure of PDB 8efe Chain A

Receptor sequence
>8efeA (length=740) Species: 9606 (Homo sapiens) [Search protein sequence]
EMAVFGAAAPYLRKSEKERLEAQTRPFDLKKDVFVPDDKQEFVKAKIVSR
EGGKVTAETEYGKTVTVKEDQVMQQNPPKFDKIEDMAMLTFLHEPAVLYN
LKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHI
FSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVLEDQIIQ
ANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSR
VIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVAS
IDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQ
AEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIY
ATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNS
FEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACID
LIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGK
PEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLTV
SALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNG
VLEGIRICRKGFPNRILYGDFRQRYRILNPASRKGAEKLLSSLDIDHNQY
KFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVL
3D structure
PDB8efe Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin.
ChainA
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A K184 T185 S242 K180 T181 S220
BS02 ADP A N126 P127 Y128 K129 S180 G181 G183 K184 T185 V186 N122 P123 Y124 K125 S176 G177 G179 K180 T181 V182
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8efe, PDBe:8efe, PDBj:8efe
PDBsum8efe
PubMed36633586
UniProtP12883|MYH7_HUMAN Myosin-7 (Gene Name=MYH7)

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