Structure of PDB 8ecc Chain A

Receptor sequence

>8eccA (length=346) Species: 10090 (Mus musculus) [Search protein sequence]

KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKGNPLSHFLEG
EVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEI
SVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAQG
ETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKK
EFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECL
RTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDK

3D structure

PDB

8ecc Structure of Ternary Complex of cGAS with dsDNA and Bound 5-pppI(2,5)pA

Chain

Resolution

2.44 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	R158 L159 K160 R161 H203 E386 K395	R10 L11 K12 R13 H55 E226 K235
BS02	dna	A	R161 S165 A168 N196 Y200 Y201 K372	R13 S17 A20 N48 Y52 Y53 K212
BS03	dna	A	K335 T338	K181 T184
BS04	dna	A	R222 K315 G316 R342	R74 K161 G162 R188
BS05	ATP	A	G198 S199 E211 D213 R364 S368 E371 K402 S420 Y421	G50 S51 E63 D65 R204 S208 E211 K242 S260 Y261
BS06	MG	A	S199 E211 D213	S51 E63 D65
BS07	ZN	A	H378 C384 C385 C392	H218 C224 C225 C232

External links

PDB	RCSB:8ecc, PDBe:8ecc, PDBj:8ecc
PDBsum	8ecc
PubMed
UniProt	Q8C6L5\|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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