Structure of PDB 8ebx Chain A

Receptor sequence

>8ebxA (length=604) Species: 9606 (Homo sapiens) [Search protein sequence]

KVDEYGAKDYRLQMPLKDDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLV
AIAEPVCRPTHVHEYKLTAYSLYAAVSVGLQTSDITEYLRKLSKTGVPDG
IMQFIKLCTVSYGKVKLVLKHNRYFVESCHPDVIQHLLQDPVIRECRLRN
SEGEATETVSFEVKQEMIEELQKRCIHLEYPLLAEYDFRNDSVNPDINID
LKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRK
RCLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSVAIST
YSMLGHTTKRSWEAERVMEWLKTQEWGLMILDEVHTIPAKMFRRVLTIVQ
AHCKLGLTATLVREDDKIVDLNFLIGPKLYEANWMELQNNGYIAKVQCAE
VWCPMSPEFYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKII
VFADNVFALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNPKINTIFISK
VGDTSFDLPEANVLIQISSHGGSRRQEAQRLGRVLRYNAFFYSLVSQDTQ
EMAYSTKRQRFLVDQGYSFKVITKLAGMEEEDLAFSTKEEQQQLLQKVLA
ATDL

3D structure

PDB

8ebx Lesion recognition by XPC, TFIIH and XPA in DNA excision repair.

Chain

Resolution

3.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

5.6.2.4: DNA 3'-5' helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	S367 A368 T393 S394 S411 M412 H415 K418 S420 Y581 R589 S608 K609	S258 A259 T284 S285 S302 M303 H306 K309 S311 Y472 R480 S499 K500
BS02	dna	A	T416 T445 A448 K449 M450 F451 R472 E473 K526 K528 H629 G631 Y672	T307 T336 A339 K340 M341 F342 R363 E364 K417 K419 H520 G522 Y554

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0003684	damaged DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016853	isomerase activity
GO:0016887	ATP hydrolysis activity
GO:0043138	3'-5' DNA helicase activity
GO:1990841	promoter-specific chromatin binding

	Biological Process
GO:0000717	nucleotide-excision repair, DNA duplex unwinding
GO:0001666	response to hypoxia
GO:0006265	DNA topological change
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006366	transcription by RNA polymerase II
GO:0006367	transcription initiation at RNA polymerase II promoter
GO:0006368	transcription elongation by RNA polymerase II
GO:0006915	apoptotic process
GO:0006979	response to oxidative stress
GO:0008104	protein localization
GO:0009411	response to UV
GO:0009650	UV protection
GO:0035315	hair cell differentiation
GO:0043065	positive regulation of apoptotic process
GO:0048568	embryonic organ development
GO:1901990	regulation of mitotic cell cycle phase transition

	Cellular Component
GO:0000112	nucleotide-excision repair factor 3 complex
GO:0000439	transcription factor TFIIH core complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005669	transcription factor TFIID complex
GO:0005675	transcription factor TFIIH holo complex
GO:0097550	transcription preinitiation complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:8ebx, PDBe:8ebx, PDBj:8ebx
PDBsum	8ebx
PubMed	37076618
UniProt	P19447\|ERCC3_HUMAN General transcription and DNA repair factor IIH helicase/translocase subunit XPB (Gene Name=ERCC3)

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