Structure of PDB 8eb0 Chain A

Receptor sequence
>8eb0A (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
LIECRCCYGEFPFEELTQCADAHLFCKECLIRYAQEAVFGSGKLELSCME
GSCTCSFPTSELEKVLPQTILYKYYERKAEEEVAAAYADELVRCPSCSFP
ALLDSDVKRFSCPNPHCRKETCRKCQGLWKEHNGLTCEELAEKDDIKYRT
SIEEKMTAARIRKCHKCGTGLIKSEGANRMSCRCGAQMCYLCRVSINGYD
HFCQHPRPCQECSRCSLWTDPTEDDEKLIEEIQKEAEEEQKRKNGENTRI
GPPLE
3D structure
PDB8eb0 The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family.
ChainA
Resolution3.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C515 C518 C537 C540 C4 C7 C26 C29
BS02 ZN A H534 C559 C564 H23 C48 C53
BS03 ZN A C605 C623 C628 C94 C112 C117
BS04 ZN A C633 H643 C122 H132
BS05 ZN A C675 C678 C693 C695 C164 C167 C182 C184
BS06 ZN A C700 C703 H712 C730 C189 C192 H201 C215
BS07 ZN A H716 C727 H205 C212
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:8eb0, PDBe:8eb0, PDBj:8eb0
PDBsum8eb0
PubMed36631489
UniProtQ9NWF9|RN216_HUMAN E3 ubiquitin-protein ligase RNF216 (Gene Name=RNF216)

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