Structure of PDB 8eaz Chain A

Receptor sequence
>8eazA (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
QQEGNYLQHVQLDQRSLVLNTEPAECPVCYSVLAPGEAVVLRECLHTFCR
ECLQGTIRNSQEAEVSCPFIDNTYSCSGKLLEREIKALLTPEDYQRFLDL
GISIAENRSAFSYHCKTPDCKGWCFFEDDVNEFTCPVCFHVNCLLCKAIH
EQMNCKEYQEDLALRAQNDVAARQTTEMLKVMLQQGEAMRCPQCQIVVQK
KDGADWIRCTVCHTEICWVTKGPRWGPGGPGDTSGGCRCRVNGIPCHPSC
QNCH
3D structure
PDB8eaz The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family.
ChainA
Resolution3.08 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.31: RBR-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C282 C285 C305 C308 C26 C29 C49 C52
BS02 ZN A C300 H302 C323 C332 C44 H46 C67 C76
BS03 ZN A C371 C376 C391 C115 C120 C135
BS04 ZN A C399 H406 C143 H150
BS05 ZN A C447 C450 C465 C191 C194 C209
BS06 ZN A C473 C493 C502 C217 C237 C246
BS07 ZN A C495 C502 C506 C239 C246 C250
External links
PDB RCSB:8eaz, PDBe:8eaz, PDBj:8eaz
PDBsum8eaz
PubMed36631489
UniProtQ9BYM8|HOIL1_HUMAN RanBP-type and C3HC4-type zinc finger-containing protein 1 (Gene Name=RBCK1)

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