Structure of PDB 8eae Chain A

Receptor sequence

>8eaeA (length=356) Species: 10090 (Mus musculus) [Search protein sequence]

DKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNT
GSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRINPLSH
FLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRN
PEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPK
NAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKL
MKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFD
KLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNG
FPIFDK

3D structure

PDB

8eae Structure of Ternary Complex of cGAS with dsDNA and Bound 5-pppG(2,5)pI

Chain

Resolution

2.56 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	R158 L159 K160 R161 H203 E386 K395	R11 L12 K13 R14 H56 E236 K245
BS02	dna	A	R161 S165 A168 N196 Y200 Y201 K372	R14 S18 A21 N49 Y53 Y54 K222
BS03	dna	A	K335 T338	K185 T188
BS04	dna	A	K315 G316 R342	K165 G166 R192
BS05	VLO	A	G198 S199 E211 D213 M215 D307 I309 R364 S366 S368 K402 C419 S420 Y421	G51 S52 E64 D66 M68 D157 I159 R214 S216 S218 K252 C269 S270 Y271
BS06	ZN	A	H378 C384 C385 C392	H228 C234 C235 C242
BS07	MG	A	E211 D213	E64 D66

External links

PDB	RCSB:8eae, PDBe:8eae, PDBj:8eae
PDBsum	8eae
PubMed	38740774
UniProt	Q8C6L5\|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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